In cases where radicalisation processes have progressed to the point that danger to self or others is imminent (or has already occurred), professional deradicalisation or disengagement assistance is required. People who have been radicalised to this point need to be addressed individually and in a targeted manner. Radicalised people are characterised by a deep mistrust of (state) institutions and representatives of the majority society. In this scenario, the decisive, often underestimated challenge is not the direct ideological confrontation, but establishing contact. People whose radicalisation (regardless of their ideological orientation) is explicitly based on their rejection of the “system” require a specific approach in order to even engage in a dialogue. A strategy based on confrontation and argumentative refutation ignoring biographical factors, which neglects this relationship factor, is counterproductive.